Martin J. Richer, Ph.D.

Assistant Professor, McGill University
Department of Microbiology & Immunology
Associate Member, Rosalind & Morris Goodman Cancer Research Centre 
McIntyre Medical Building - Room 712
3655 promenade Sir William Osler
Montreal, QC, Canada H3G 1Y6 
T 514-398-4400 Office Ext.: 00538, Lab Ext.: 04510

E-mail: martin.j.richer(at)mcgill.ca

Updated: February 18, 2020

Dominic G. Roy Ph.D.
Postdoctoral Fellow
supported by a PDF from CIHR
Current Position
Sept 2017-present Postdoctoral Fellow
Department of Physiology
McGill University, Montreal, QC, Canada
dominic.roy(at)mcgill.ca
Supervisor Dr. Russell Jones, co-supervised by Dr. Martin J. Richer
Training

2009-2016 Doctor of Philosophy

Department of Biochemistry, Microbiology & Immunology

Biochemistry: Specialization in Human and Molecular Genetics

University of Ottawa, Ottawa, ON, Canada

Supervisor Dr. John Bell

2004-2009 Bachelor of Science (Honours)

Department of Biochemistry, Microbiology & Immunology

Biochemistry with CO-OP

University of Ottawa, Ottawa, ON, Canada

Honours project supervisor Dr. John Bell

Research Interests
My Ph.D. focused on the use of oncolytic viruses as cancer therapeutics, with my research aimed at improving the delivery and replication of oncolytic viruses. Since oncolytic viruses are a form of immunotherapy, I developed an interest in immunology and immunotherapy during my Ph.D. For my postdoctoral studies, I decided to dive into the field of immunometabolism. I am interested in how cellular metabolism affects T cell development and function, with a focus on anti-tumor immunity and T cell exhaustion. My research aims to characterize the metabolic state of exhausted T cells and to identify metabolic networks that contribute to the development and survival of exhausted T cells, with the goal of identifying strategies to reinvigorate T cell function. On my spare time, I like to fish, play hockey and spend time with my wife and my dog.
Selected publications

Raud B#, DG Roy#, AS Divakaruni, TN Tarasenko, R Franke, EH Ma, B Samborska, WY Hsieh, AH Wong, P Stüve, C Arnold-Schrauf, M Guderian, M Lochner, S Rampertaap, K Romito, J Monsale, M Brönstrup, SJ Bensinger, AN Murphy, PJ McGuire, RG Jones, T Sparwasser and L Berod. Etomoxir actions on regulatory and memory T cells are independent of Cpt1a-mediated fatty acid oxidation. Cell Metabolism 2018: 28(3): 504-515.e7. PMID: 30043753. #Authors contributed equally

Tzelepis F, J Blagih, N Khan, J Gillard, L Mendonca, DG Roy, EH Ma, R Joubert, RG Jones and M Divangahi. Mitochondrial cyclophilin D regulates T cell metabolic responses and disease tolerance to tuberculosis. Science Immunology 2018: 3(23). PMID: 29752301.

 

Bourgeois-Daigneault MC, DG Roy, AS Aitken, N El Sayes, NT Martin, O Varette, T Falls, LE St-Germain, A Pelin, BD Lichty, DF Stojdl, G Ungerechts, JS Diallo and JC Bell. Neoadjuvant oncolytic virotherapy before surgery sensitizes triple-negative breast cancer to immune checkpoint therapy. Science Translational Medicine 2018: 10(422). PMID: 29298865.

 

Roy DG, AT Power, MC Bourgeois-Daigneault, T Falls, L Ferreira, A Stern, C Tanese de Souza, JA McCart, DF Stojdl, BD Lichty, H Atkins, RC Auer, JC Bell and F Le Boeuf. Programmable insect cell carriers for systemic delivery of integrated cancer biotherapy. Journal of Control Release 2015: 220(Pt A): 210-221. PMID: 26482080.

 

Roy DG and JC Bell. Cell carriers for oncolytic viruses: current challenges and future directions. Oncolytic Virotherapy 2013: 2: 47-56. eCollection 2013. PMID: 27512657. Review.

full publication list on PubMed