Martin J. Richer Laboratory
Stephanie A. Condotta Ph.D.
Assistant Research Professor
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Current Position
Nov 2020-present
Department of Microbiology and Immunology
Indiana University School of Medicine
Indianapolis, IN, USA
sacondot(at)iu.edu
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Training
2015-2020 Research Associate
Department of Microbiology & Immunology
McGill University, Montreal, QC, Canada
Supervisor Dr. Martin J. Richer
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2014-2015 Postdoctoral Fellow
Department of Microbiology & Immunology
McGill University, Montreal, QC, Canada
Supervisor Dr. Martin J. Richer
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2010-2014 Postdoctoral Research Scholar
Department of Pathology
The University of Iowa, Iowa City, IA, USA
Supervisor Dr. Vladimir P. Badovinac
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2005-2010 Doctor of Philosophy
Department of Microbiology & Immunology
The University of British Columbia, Vancouver, BC, Canada
Supervisor Dr. François Jean
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2002-2005 Master of Science
Department of Biology, Centre for Biotechnology
Brock University, St. Catharines, ON, Canada
Supervisors Dr. Michael Bidochka and Dr. Fiona Hunter
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1997-2002 Bachelor of Science (Honours)
Department of Biology, Centre for Biotechnology
Brock University, St. Catharines, ON, Canada
Honours project supervisor Dr. Michael Bidochka
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Research Interests
My dad was a high school science teacher and introduced me to science at a very young age. There was always fun experiments going on at home and I was hooked after he showed me a paramecium slide with our microscope at home. I fell in love with scientific research during my undergraduate honours project working on insect pathogenic fungus. I wanted to continue academic research for my M.Sc. degree and had the opportunity to study the epidemiology of West Nile virus in Ontario, Canada. I wanted to further my understanding of West Nile virus and for my Ph.D. research I studied the biochemical mechanisms of the West Nile virus NS3 protease. From here I changed gears and decided I wanted to learn something totally new for my postdoctoral training. I had the opportunity to learn immunology and focused my research on the impact sepsis has on CD8 T cell responses to infection. This experience opened up a whole new world and I fell in love with CD8 T cells. My current research in the Richer lab focuses on furthering our understanding of CD8 T cell biology in context of infectious models and disease. When I'm not in the lab I enjoy watching TV, experimenting in the kitchen, cycling, walking in the one of the amazing parks in Indy and hanging out with our crazy, adorable, very affectionate cat Wren.
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Selected publications
Dhalech, A, C Corn, V Mangale, F Syed, SA Condotta, MJ Richer and CM Robinson. Testosterone promotes intestinal replication and dissemination of Coxsackievirus B3 in an oral inoculation mouse model. Journal of Virology 2022: 96(17): 1-16. PMID 36037480.
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Pardy, RD, ME Gentile, AM Carter, SA Condotta, IL King and MJ Richer. An epidemic Zika virus isolate drives enhance T follicular helper cell and B cell-mediated immunity. Journal of Immunology 2022: 208(7): 1719-1728. PMID: 35346966.
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Condotta, SA, J Downey, RD Pardy, SF Valbon, E Tarrab, A Lamarre, M Divangahi and MJ Richer. Cyclophilin D regulates antiviral CD8+ T cell survival in a cell extrinsic manner. ImmunoHorizons 2020: 4(4): 217-230. PMID: 32332052.
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Smith, LK, GM Boukhaled, SA Condotta, S Mazouz, JJ Guthmiller, R Vijay, NS Butler, J Bruneau, NH Shoukry, CM Krawczyk and MJ Richer. Interleukin-10 directly inhibits CD8 T cell function by enhancing N-glycan branching to decrease antigen sensitivity. Immunity 2018: 48(2): 299-312. PMID: 2939160.
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Pardy, RD, MM Rajah, SA Condotta, NG Taylor, SM Sagan and MJ Richer. Analysis of the T cell response to Zika virus and identification of a novel CD8 T cell epitope in immunocompetent mice. PLOS Pathogens 2017: 13(2): e1006184. PMID: 28231312.
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Ma EH, G Bantug, T Griss, SA Condotta, RM Johnson, B Samborska, N Mainolfi, V Suri, H Guak, ML Balmer, MJ Verway, TC Raissi, H Tsui, G Boukhaled, S Henriques da Costa, C Frezza, CM Krawczyk, A Friedman, M Manfredi, MJ Richer, C Hess and RG Jones. Serine is an essential metabolite for effector T cell expansion. Cell Metabolism 2017: 25(2): 345-357. PMID: 28111214.
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Condotta SA and MJ Richer. The immune battlefield: The impact of inflammatory cytokines on CD8 T cell immunity. PLoS Pathogens Pearls 2017: 13(10): e1006618. PMID: 29073270. Review.
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Rajah, MM, RD Pardy, SA Condotta, MJ Richer and SM Sagan. Zika Virus: Emergence, Phylogenetics, Challenges and Opportunities. ACS Infectious Diseases 2016: 2(11): 763-772. PMID: 27704772. Review.
Valbon, SF#, SA Condotta# and MJ Richer. Regulation of effector and memory CD8 T cell function by inflammatory cytokines. Cytokine 2016: 82: 16-23. PMID: 26688544. #Authors contributed equally. Review.
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